abstract：:The case of a 34-yr-old Caucasian male with Graves' disease presenting with a flaccid quadriplegia and severe hypokalemia is reported. The weakness was prevalent at the lower extremities and began during nocturnal sleep, after a strenuous physical exertion performed during the day. Correction of hypokalemia promptly r...

journal_title：Journal of endocrinological investigation

authors： Celani MF,Bonati ME,Cavalli M

更新日期：1995-03-01 00:00:00

abstract：:We evaluated the 24-h profile of serum melatonin (MT) in 16 patients with Cushing's syndrome (11 pituitary- and 5 adrenal-dependent) aged 38.1 +/- 13.8 years and in 19 patients with acromegaly due to GH-secreting pituitary adenoma aged 52 +/- 11.9 years. Thirty-three healthy subjects aged 30 +/- 7 years and 26 healthy...

journal_title：Journal of endocrinological investigation

authors： Terzolo M,Piovesan A,Alì A,Codegone A,Pia A,Reimondo G,Torta M,Paccotti P,Borretta G,Angeli A

更新日期：1995-01-01 00:00:00

abstract：:Abnormalities of the gene encoding the sequence-specific DNA-binding protein, nuclear phosphorprotein p53, are among the most common genetic alterations observed in human cancers. A mutation of this tumor suppressor gene has been reported with a low prevalence in differentiated thyroid carcinomas, while the prevalence...

journal_title：Journal of endocrinological investigation

authors： Iyota K,Takeda K,Matsuzuka F,Okabayashi T,Morita S,Kuma K,Hashimoto K

更新日期：1994-11-01 00:00:00

abstract：:Pyridinoline (Pyr) and deoxypyridinoline (D-Pyr) are two cross-links of collagen molecules, that are present in the extracellular matrix and released during its degradation. Pyr is present in bone and cartilage, but not in significant amounts in other connective tissues and D-Pyr appears to be specific for bone tissue...

journal_title：Journal of endocrinological investigation

authors： Calabresi E,Lasagni L,Franceschelli F,de Leonardis V,Becorpi A,Serio M,Brandi ML

更新日期：1994-09-01 00:00:00

abstract：:This report describes the results of the second part of the collaborative study organized by a working group sponsored by the Community Bureau of Reference of the European Community Commission. The whole study was designed to understand the causes of discrepancy among LH immunoassay methods. In the parent report we de...

journal_title：Journal of endocrinological investigation

authors： Costagliola S,Niccoli P,Florentino M,Carayon P

更新日期：1994-06-01 00:00:00

abstract：:We describe a patient with Cushing's syndrome and metastatic small cell lung cancer. The plasma ACTH concentrations were markedly elevated (91.6 pmol/L), and the AM cortisol did not suppress by > 50% overnight after administration of 8 mg dexamethasone, both consistent with the ectopic ACTH syndrome. Immunohistochemic...

journal_title：Journal of endocrinological investigation

authors： Auchus RJ,Mastorakos G,Friedman TC,Chrousos GP

更新日期：1994-06-01 00:00:00

abstract：:Severe bleeding into the peritoneal cavity from a ruptured ovulatory follicle is a rare complication in women receiving anticoagulation therapy. A number of both surgical and non surgical methods have been proposed to solve this problem. We adopted a novel therapeutic approach in a 40-year old patient who presented wi...

journal_title：Journal of endocrinological investigation

authors： Ulrich U,Rossmanith WG

更新日期：1994-05-01 00:00:00

abstract：:A 45-year-old man presented with gynecomastia, hypertension and a large left adrenal mass. Further evaluation revealed elevated serum concentrations of estrogen, estrone sulfate, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, deoxycorticosterone, and aldosterone and increased 24-hour urinary ...

journal_title：Journal of endocrinological investigation

authors： Zayed A,Stock JL,Liepman MK,Wollin M,Longcope C

更新日期：1994-04-01 00:00:00

abstract：:In order to precise the relationships between TSH, FT3, and FT4 nycthemeral variations and the relationships between thyroid hormone variations and sleep, 8 healthy young males were studied twice, once during a 24-h experiment with normal nocturnal sleep, and once during a night of sleep deprivation. The subjects rece...

journal_title：Journal of endocrinological investigation

authors： Goichot B,Brandenberger G,Saini J,Wittersheim G,Follenius M

更新日期：1994-03-01 00:00:00

abstract：:Reportedly, the responsiveness of somatotrope cells to GHRH is reduced in elderly humans but it is totally restored by arginine (ARG) which likely acts by inhibiting hypothalamic release of somatostatin. As this effect was observed after infusion of high doses of the amino acid, in this study, we compared the effect o...

journal_title：Journal of endocrinological investigation

authors： Ghigo E,Ceda GP,Valcavi R,Goffi S,Zini M,Mucci M,Valenti G,Cocchi D,Müller EE,Camanni F

更新日期：1994-02-01 00:00:00

abstract：:We report here on the isolation and repertoire characterization of a Graves' thyroid T cell population which, unlike most Graves' thyroid T cell isolates reported before, was rich in CD4-CD8- T cells (16%, all TcR gamma delta+) and CD8+ T cells (75%) [TcR alpha beta+ (59%) and TcR gamma delta+ (16%)]. Only 7% of the i...

journal_title：Journal of endocrinological investigation

authors： Santamaria P,Lewis C,Barbosa JJ

更新日期：1993-12-01 00:00:00

abstract：:N-Methyl-D-Aspartate(NMDA)-sensitive glutamate receptors, are critically involved in the induction of the learning process. Activation of NMDA receptors by glutamate lead to massive influx of extracellular Ca2+, with ensuing activation of a variety of Ca(2+)-dependent enzymes, including protein kinase C. This triggers...

journal_title：Journal of endocrinological investigation

authors： Caruso S,Agnello C,Campo MG,Nicoletti F

更新日期：1993-12-01 00:00:00

abstract：:Eighteen patients affected by laparoscopically confirmed endometriosis were randomly assigned to three different schedules of treatment with gonadotropin-releasing hormone agonist (GnRH-a) (goserelin depot formulation 3.6 mg) every 28 days for 6 months. Six women received the first implant in early follicular phase, 4...

journal_title：Journal of endocrinological investigation

authors： Magini A,Pellegrini S,Tavella K,Forti G,Massi GB,Serio M

更新日期：1993-11-01 00:00:00

abstract：:We have measured eye muscle antibodies, in immunoblotting, in the serum from five patients with severe ophthalmopathy associated with Graves' hyperthyroidism who underwent plasmapheresis, correlating their levels with clinical features of the eye disorder and response to treatment. Blood taken before each plasma excha...

journal_title：Journal of endocrinological investigation

authors： Atabay C,Schrooyen M,Zhang ZG,Salvi M,Glinoer D,Wall JR

更新日期：1993-10-01 00:00:00

abstract：:Gonadal sex hormones may account for the sexual dimorphism in the immune response and for the greater incidence of autoimmune disease in females. We have previously reported the presence of progesterone (P) deficiency in female patients with thyroid and ovarian autoimmune disease. In this context, the hormonal profile...

journal_title：Journal of endocrinological investigation

authors： Valentino R,Savastano S,Tommaselli AP,Riccio A,Mariniello P,Pronesti G,De Divitiis PM,Lombardi G

更新日期：1993-09-01 00:00:00

abstract：:Circulating TSH bioactivity may vary in several clinical and experimental conditions. Since the reliability of the current methods for the measurement of TSH bioactivity is limited, a new bioassay based on cAMP accumulation in Chinese Hamster Ovary cells transfected with recombinant human TSH receptor (CHO-R) was set ...

journal_title：Journal of endocrinological investigation

authors： Persani L,Tonacchera M,Beck-Peccoz P,Vitti P,Mammoli C,Chiovato L,Elisei R,Faglia G,Ludgate M,Vassart G

更新日期：1993-07-01 00:00:00

abstract：:In healthy pregnant women, the regulation of thyroid function depends upon several factors. Three factors act independently to increase thyroid hormone requirements: 1) the marked increase in the binding capacity of serum due to high TBG levels; 2) the direct stimulation of the thyroid by human chorionic gonadotropin,...

journal_title：Journal of endocrinological investigation

authors： Glinoer D

更新日期：1993-05-01 00:00:00

abstract：:Growth hormone (GH), insulin-like growth factor-1 (IGF-1) and prolactin (PRL) in blood and urine were observed in 20 patients with acromegaly in a double-blind placebo-controlled 14-day clinical trial with the somatostatin analog octreotide. Hormones were determined by the same radioimmunoassays in blood and urine. Si...

journal_title：Journal of endocrinological investigation

authors： Fredstorp L,Werner S

更新日期：1993-04-01 00:00:00

abstract：:Eight-year follow-up evaluation and analysis of factors related to postoperative thyroid dysfunction were made in 216 patients with Graves' disease treated by subtotal thyroidectomy. The postoperative status of thyroid function were as follows according to hypersensitive TSH level: 65 patients (30.1%) were euthyroid, ...

journal_title：Journal of endocrinological investigation

authors： Sugino K,Mimura T,Toshima K,Iwabuchi H,Kitamura Y,Kawano M,Ozaki O,Ito K

更新日期：1993-03-01 00:00:00

abstract：:This study, carried out on 9 nonfunctioning pituitary adenomas, was undertaken in order to evaluate the ability of these tumors to synthesize and release gonadotropins and/or free alpha-subunit (alpha-SU) of glycoproteins. The morphological study included electron microscopy and immunofluorescence analysis while hormo...

journal_title：Journal of endocrinological investigation

authors： Saccomanno K,Gil del Alamo P,Bassetti M,Reza-Elahi F,Spada A

更新日期：1993-02-01 00:00:00

abstract：:Follicular thyroid carcinoma may spread distant metastases in sites such as bone, lung and brain. In our series of 448 patients with follicular thyroid carcinoma, distant metastases were present in 25% of cases. We report here a case of follicular thyroid carcinoma with a single metastasis at the right adrenal gland, ...

journal_title：Journal of endocrinological investigation

authors： Girelli ME,Casara D,Rubello D,Piccolo M,Piotto A,Pelizzo MR,Busnardo B

更新日期：1993-02-01 00:00:00

abstract：:Endemic goiter in Morocco is localized in the Rif and Atlas mountains. In this study, performed in the Skoura-Toundoute areas (high Atlas), we demonstrate that iodine deficiency is the main factor involved in the development of endemic goiter. However it may not constitute the only etiological factor. The median urina...

journal_title：Journal of endocrinological investigation

authors： Aquaron R,Zarrouck K,el Jarari M,Ababou R,Talibi A,Ardissone JP

更新日期：1993-01-01 00:00:00

abstract：:According to recent studies showing the presence of estrogens receptors (ERs) in the human female lower urinary tract, we performed ER and progesterone receptor (PR) assays in fresh frozen and paraffin embedded biopsies taken from the urinary bladder. Fourteen females undergoing endoscopy during staging for gynecologi...

journal_title：Journal of endocrinological investigation

authors： Pacchioni D,Revelli A,Casetta G,Cassoni P,Piana P,Tizzani A,Bussolati G,Massobrio M

更新日期：1992-11-01 00:00:00

abstract：:A 57-year-old man with pituitary metastasis from renal cell carcinoma is reported. He underwent right nephrectomy and total pancreatectomy for renal cell carcinoma and its pancreatic metastasis, respectively. Imaging studies showed an intrasellar mass lesion. The examination revealed panhypopituitarism, diabetes insip...

journal_title：Journal of endocrinological investigation

authors： Koshiyama H,Ohgaki K,Hida S,Takasu K,Yumitori K,Shimatsu A,Koh T

更新日期：1992-10-01 00:00:00

abstract：:The cause of a poor response to human menopausal gonadotropin (hMG) remains unexplained. To determine whether aromatase activity of cultured granulosa cells obtained from relatively low estradiol (E2) responders (serum E2 < 1000 pg/ml) to hMG therapy differed from that of good responders (E2 > or = 1000 pg/ml), we pro...

journal_title：Journal of endocrinological investigation

authors： Hurst BS,Zacur HA,Schlaff WD,Berkovitz GD

更新日期：1992-09-01 00:00:00

abstract：:To determine the role of endogenous opioid peptides in regulating pulsatile luteinizing hormone (LH) release in the early follicular phase of the menstrual cycle of eumenorrheic women, we evaluated serum LH concentrations in blood collected every 10 min for 12 h in 27 women each studied during two menstrual cycles: (1...

journal_title：Journal of endocrinological investigation

authors： Evans WS,Weltman JY,Johnson ML,Weltman A,Veldhuis JD,Rogol AD

更新日期：1992-07-01 00:00:00

abstract：:The Nb2 rat lymphoma bioassay (BA) for prolactin (PRL) was performed in 26 subjects with hyperprolactinemia, 17 of whom had radiologic evidence of a pituitary adenoma. All subjects were treated with the long acting dopamine agonist CV 205-502. The radioimmunoassay (RIA) PRL significantly decreased with treatment but t...

journal_title：Journal of endocrinological investigation

authors： Peabody CA,Schultz PN,Warner MD,Worsley IG,Friesen HG,Samaan NA

更新日期：1992-07-01 00:00:00

abstract：:Up to now, the diagnosis of silent corticotroph cell pituitary adenomas has been made only on histopathological basis. In this paper we describe 6 women affected with pituitary adenomas, without evident clinical features of hypercortisolism, in whom retrospective data suggested the possibility of clinically diagnosing...

journal_title：Journal of endocrinological investigation

authors： Ambrosi B,Colombo P,Bochicchio D,Bassetti M,Masini B,Faglia G

更新日期：1992-06-01 00:00:00

abstract：:Established methods for definitive ablation of autonomous thyroid nodules are surgery and radioiodine. Since it has been demonstrated that percutaneous ethanol injection can inactivate parathyroid adenomas and small hepatocellular carcinomas, we started a trial of this treatment in patients with autonomous thyroid nod...

journal_title：Journal of endocrinological investigation

authors： Paracchi A,Ferrari C,Livraghi T,Reschini E,Macchi RM,Bergonzi M,Raineri P

更新日期：1992-05-01 00:00:00

abstract：:We summarized the clinical course of 10 patients with silent thyroiditis and evaluated the clinical usefulness of ultrasonography, in combination with clinical and laboratory findings, for the differentiation from Graves' disease. Serum T3 and T4 were increased in all cases, and the ratio of T3/T4 (ng/micrograms) was ...

journal_title：Journal of endocrinological investigation

authors： Miyakawa M,Tsushima T,Onoda N,Etoh M,Isozaki O,Arai M,Shizume K,Demura H

更新日期：1992-04-01 00:00:00

abstract：:A case of malignant islet-cell tumor with oncocytic features occurring in a 54-year-old woman with symptoms of organic hypoglycemia is reported. The tumor was composed of ribbons of cells arranged in an endocrine pattern. The cytoplasm of these cells was eosinophilic and finely granular. Ultrastructurally, the cells c...

journal_title：Journal of endocrinological investigation

authors： Sadoul JL,Saint-Paul MC,Hoffman P,Plazza M,Birtwisle Y,Freychet P,Loubiere R

更新日期：1992-03-01 00:00:00

abstract：:This is a brief case report on a four-month-old girl who was admitted for failure to thrive and moderate dehydration. On admission she was mildly dehydrated and undernourished but with otherwise normal physical findings. Laboratory investigation disclosed mild but constant hyponatremia and hyperkalemia, very high plas...

journal_title：Journal of endocrinological investigation

authors： Mardesić D,Sarnavka V,Dumić M,Stipić V

更新日期：1992-03-01 00:00:00

abstract：:Iodine balance during pregnancy and lactation was investigated by measuring iodine concentration in the urine of 11 pregnant women, born and living in a moderately iodine deficient endemic goiter area in Northeastern Sicily, collected during the last week of pregnancy, and between the 5th and 7th day after delivery, a...

journal_title：Journal of endocrinological investigation

authors： Vermiglio F,Lo Presti VP,Finocchiaro MD,Battiato S,Grasso L,Ardita FV,Mancuso A,Trimarchi F

更新日期：1992-02-01 00:00:00

abstract：:A 56-year-old woman with granulomas of gold thioglucose in her hips exhibited recurrent bouts of hypoglycemic attacks. The first attack occurred 2 years after the last injection of gold thioglucose, when large amounts of extractable insulin and human insulin-specific antibody were noted in her serum. Histological exam...

journal_title：Journal of endocrinological investigation

authors： Yao K,Uchigata Y,Kyono H,Yokoyama H,Eguchi Y,Fukushima H,Yamauchi K,Hirata Y

更新日期：1992-01-01 00:00:00

abstract：:Seventy-one white women within 6 months to 6 years postmenopause were randomly assigned to three treatment groups: (a) placebo, (b) calcium, (c) cyclic estrogen-progestin plus calcium. Calcium was given as calcium carbonate with meals to attain an intake of 1,700 mg daily in the latter two groups. All women received 4...

journal_title：Journal of endocrinological investigation

authors： Aloia JF,Vaswani A,Yeh JK,McGowan DM,Ross P

更新日期：1991-12-01 00:00:00

abstract：:Much research has demonstrated that in late pregnancy glucose administration causes a marked increase of peripheral insulin levels. To ascertain whether this particular increase is due to increased insulin secretion and/or to reduced hepatic insulin removal, we measured blood glucose, plasma C-peptide and plasma insul...

journal_title：Journal of endocrinological investigation

authors： Piva I,Erle G,Thiella M,Lora L,Strazzabosco M,Sicolo N,Federspil G

更新日期：1991-11-01 00:00:00

abstract：:The role of thyroid hormones in a short loop feedback in the thyroid is controversial. This process was studied in dog thyroid slices stimulated by TSH, carbachol and phorbol esters. Incubation of thyroid slices with T3 and T4 for 1 hour inhibited the subsequent stimulation of glucose oxidation induced by carbachol an...

journal_title：Journal of endocrinological investigation

authors： Pasquali D,Bellastella A,Field JB

更新日期：1991-11-01 00:00:00

abstract：:We evaluated the effect of six-month treatment with growth hormone (GH) or low-dose oxandrolone in a group of boys with constitutional growth delay (CGD). Sixteen boys were randomly assigned to two treatment groups. Group 1 received GH (0.6 U/kg/week sc 5-6 times/week) and Group 2 received oxandrolone (0.07 mg/kg po)....

journal_title：Journal of endocrinological investigation

authors： Loche S,Pintor C,Cambiaso P,Lampis A,Carta D,Corda R,Cappa M

更新日期：1991-10-01 00:00:00

abstract：:We herein describe a family with thyroid hormone resistance. Thyroid hormones and basal TSH were elevated. Pituitary tumor or abnormality in thyroid hormone binding proteins were ruled out by appropriate tests. Mother and sister of the propositus presented similar abnormal hormonal features but no hyperthyroidism. Ini...

journal_title：Journal of endocrinological investigation

authors： Aguilar Diosdado M,Escobar-Jimenez L,Fernandez Soto ML,Garcia Curiel A,Escobar-Jimenez F

更新日期：1991-09-01 00:00:00

abstract：:The case is described of a woman with a Verner-Morrison syndrome of extreme severity, caused by an occult VIPoma. Administration of SMS 201-995 (Sandoz) (SMS) at the dose of 150 and subsequently of 250 micrograms daily, decreased plasma levels of vasoactive intestinal polypeptide (VIP) from about 500 to 100 pg/ml (hig...

journal_title：Journal of endocrinological investigation

authors： Brunani A,Crespi C,De Martin M,Dubini A,Piolini M,Cavagnini F

更新日期：1991-09-01 00:00:00